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Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules that widely exist in various organisms. Unlike traditional linear mRNAs, circRNAs lack 5' and 3' ends and thus resistant to RNA exonucleases-mediated degradation. As a result, they are more stable both in vivo and in vitro.
For a long time, circRNAs have been considered as a long non-coding RNAs. The recent work by CirCode team showed that circRNAs can be translated produce functional proteins in a cap-independent manner using IRESs, RNA modifications, or IRES-like elements (ref 1-3). CircRNA is an ideal platform for next-generation mRNA therapies due to its high stability, low immunogenicity, and cell-specific translation.
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About circRNA
Technical Features of circRNA
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Based on our knowledge of circRNA, CirCode team has developed a proprietary technology platform that can robustly produce circRNAs in a large scale with high translation efficiency.This technology has been applied in developing explore more effective therapeutic drugs.
CirCode is committed to promoting the transformation of scientific and technological achievements and realizing the benefit of science and technology for mankind.
Room 901, No.8,Jiafeng Road
Pudong New District,Shanghai
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Cooperation and media, please contact
info@circodebio.com
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